Ask Our Doctors – Archive
Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.
Hi Dr Sher, in what situations would you recommend using Estrogen tablets and progesterone (after ovulation) when doing a cycle with Clomid or Femara (trying to get pregnant naturally)? Is this a protocol that you use? Many thanks in advance.
I would not take that approach after clomiphene or Letrozole therapy!
Geoff Sher
Hello Dr. Sher
I am currently going to Sher NY and a patient of Dr.T since 2016.
My husband and I are 50% DQalpha match, and my NK cell is pretty activated slightly above the borderline.
Feb 2017, I had FET with one PGS tested normal blastsyst. I was under interlipid infusion treatment for every 3weeks, predonizone 20mg, estrace and PIO 10mg/night.
I got pregnant and everything seemed fine, but I got miscarriage on my 15th week. I had D&C in may 2017. The Fetus biopsy result came back normal, so we could not find the reason.
But later on my hematologist found that I have two gene mutation that may cause blood clotting.
I came back to Sher and restarted with egg retrieval, and I got 3pgs normal blastocyst.
November 2017
I had 2nd FET using the same methods but adding heparin and transferred one pgs normal blastsyst. It had implanted, but ended up in chemical pregnancy.
After the incidence, I had endometrium biopsy and found out I had Chronic Endometriticis. So I took Doxyciclyne for 2 weeks and it was treated completely.
March 2018
My 3rd FET using the same method as the second FET. One PGS normal blastocyst was transferred on 3/29/2018, I got positive beta of 64 on 8dpt, but the next beta was only77 on12dpt and I am expecting to have another chemical pregnancy.
Dr.T does not know why I am having recurrent chemical pregnancies especially with using PGS normal embryos and suggested me to see an immunologist to get tested to find the cause.
I don’t want to give up and I am willing to do anything if I am able to conceive one more time. But I am 40 years old and I don’t have much time left, plus I have only one more PGS tested blastocyst.
Dr. Sher,
Would you please help me? Have you had a patient like my case with any successful result? Would you please suggest me any additional immunological test that I should take prior to the next transfer? Or can you think of any problem that may be causing this recurrent chemical pregnancy?
I am so hopeless right now. Dr.T and I tried everything we could do but did not work anyhow.
Would you please kindly advise?
P.S. I am sorry about my English, I am Japanese and English is my second language.
Hope to hear from you.
Yuki
In ordrr for the IL to work well, it needs to be combined with prednisone therapy. Hopefully you are receiving both. The IL down-regulates NK -activity but does not impact activation of T-cells which can occur concomitantly. The steroid acts to down-regulate cytotoxic T-cells. Discuss with Dr T.
Ultimately, if this treatment fails, you might have to entertain the possibility of Gestational surrogacy.
Geoff Sher
Dear Dr. Sher
Is it fine to ask a second valuable opinion from you?
Anytime!
Geoff Sher
HEY TRUST ALL IS GOOD FOR YOUR INFOMATION WE ADPOTED CHILD 2016 NOW IN SCHOOL BUT MADAM YUNIAH HAS HEAVY PEROIDS LOND AS MOE 7 DAYS HOW CAN YOU ADVISE AS U KNOW THOUGH YOUR ADVISE TO DR. NOREH WE DID IVF BUT MISCARRIED
THANKS WELCOME
YUNIAH MAOGA/SIMPSON
+254724763805 , 0786578910
Please discuss this with your personal OB/GYN.
Geoff Sher
Hello Dr. Sher,
Thank you for everything you do!
I have a question about implanting embryos. Would you take a PGS normal embryo and an embryo with a single Monosomy and implant them? In your opinion, does the abnormal (hopefully just Mosaic) embryo have a bad effect on the normal embryo? Will it help the chances of a successful implantation? No uterine or lining issues in the womb.
Kind regards,
MC
Yes I would! In my opinion it would not likely adversely affect the ability of the other embryo to attach.
Geoff Sher