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Dear Dr. Sher,
Thank you for your blog, it has lots of information for the newbies to IVF like me.
My husband and I are 35 and just completed our first round of IVF with PGS. We found out today that one is a normal 4AA (morphokinetic=A ) day 6 hatching blastocyst and another 4BB (morphokinetic=B ) day 6 hatching blastocyst with mosaic loss (30ML) in chromosome 20. Would you recommend transferring the mosaic embryo with the normal one? If yes, would it affect the chances of the normal one? Would you recommend transferring the mosaic alone, would it stand a good chance of normal live birth?
Sincerely appreciate your advice.
Yes I would, and in my opinion, this would not prejudice the chance of the euploid one taking.
Good luck!
Geoff Sher
Hi Dr sher
Which pair do you prefer to transfer
4aa and 3bb 5dayblast embryo or 6a and 2bc 6dayblaat embryos
All 4 are worthy of transfer but I would give preference to the day-5 blasts!
Geoff Sher
Hi Dr sher cd20 i had two frozen 6day blast embryo transfer.
7days past transfer (that is excactly the time of my 28day ciclus) i had White Brown spot like epitelium issue or blood plug Day 8 it is black issue one or two in a Day.. I dont use jel vaginally but Just vaginall tablet of progestronand i put it gently and not through deep
Could it be implantation bleeding this kate. Or is my period try to start and and these issues are the leak of blood
Not likely…but I would not be overly concerned!
Geoff Sher
Hi doc. Our 28yr old surrogate just had a 5day FET. The embryo had been PGS tested normal. She’s 4weeks 3days & her 1st HCG came back at 52. Is this reason to worry? We’re a tad bummed. Thx for insights.
Repeat in 2 days. It should be >100. If so, things are likely to turn out fine!
Good luck!
Geoff Sher
Hi Dr. Sher,
I am doing a frozen embryo transfer in two days and they started me on pregesterone three days ago (so five days in total of pregesterone prior to transfer). I have been taking 300 mg of prometrium orally at night and 200mg 3 times per day of prometrium capsules vaginally. Problem is that I took a progesterone blood test today and it came back slightly low levels of pregesterone (dr said 33 when it should be at least 40). He’s telling me we can still go through with the transfer because pregesterone levels could easily be corrected even within hours so he told me to take 600mg orally of prometrium at night (instead Of the 300 mg I’ve been taking). He thinks that will make a difference. I’m concerned that I don’t have enough time to correct this low level because my transfer is in two days. What do you think? Also, will low progesterone level in my body cause the transfer to be a failure and prevent me getting pregnant? Do I have to cancel my cycle and start again next time? Please let me know.
Thank you,
Sherry
I would concur with the opinion expressed by your RE.
Good luck!
Geoff Sher
In my practice, I avoid giving androgens, especially when it comes to women with DOR (as is likely the case with you). I would agree with using HGH.
Good luck!
Sher