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We have MF due to my husband missing a speed duct, so IVF is our only option for a biological child. We just completed our 3 full IVF cycle for a total of 5 embryo. We have a daughter with one normal embryo and just implanted our final grade AA PGS normal embryo which failed. We had one miscarriage last summer, but haven’t had any other success transfers. I’m not sure why the embryos keep failing since had lining over 8mm and saline sonogram was normal. Any suggestion of what we are missing? BTW- I’ll be 40 in 5 months. Thanks
Dear Dr. Geoffrey,
I had two successful full term births with my husband (2016 – pregnant first try& 2018- pregnant third cycle), we have been trying to complete our family since last April. I had a 8 week miscarriage in September 19’, a 5 week chemical in November and now another chemical in February 20’. I’ve asked my OB for help but feel like I’m being ignored because I’ve had two full term pregnancies. Any thoughts? Where can I go from here? Thank you! Mrs. K
What would you say the best thickness for endometrial lining is for a fet? I have naturally thick lining(my body loves the estradiol,I did a d&c and the next month was still thick). Usually 18-20.
Endometrium that reaches at least 8mm on estrogen (prior to progesterone administration or the “trigger” is OK. There is no such thing as “too thick” lining. As long as there is no pathology!
Geoff Sher
Hi dr. Sher,
I’m 26 years old, and my husband is 33. We had one successful pregnancy in 2014., early on relathionship (6 months), resulting with healthy full term baby. That was my first pregnancy ever.
From September 2018. we are trying for new baby. I was pregnant in 2nd cycle of trying and then miscarried on 10w2d. Specialist performed curettage on me. From then till now i had 5 biochemical pregnancies proven with beta hcg from blood.
My papa test, thyroid and hormones are ok, I also did coagulation blood tests for trombophilia and that is also ok. I have just one mutation on PAI 1- homozigot 5G. My husband’s spermiogram is classified as asthenozoospermia. My beta hcg levels in biochemicals never went beyond 29.5 IU/L.
I hope that you can understand me ,I’m from Europe.
I would really appreciate if You could give me some advice!
Hi Dr Sher,
I had a fresh transfer of a cavitating blastocyst (we decided to save my 4AB blastocyst for frozen transfer as I had a progesterone rise of day of trigger).
I was spotting since 5 days post transfer so did an early beta HCG at 9 days post transfer and to my surprise HCG was 28. 2 days later (11dpt) it rose to 90, but my bleeding increased so my dr added miniaspirin and a day later, I passed a large clot (5-6cm in diameter). We repeated HCG the next morning (13dpt) and again to my surprise it was 198. Progesterone has been stable around 50nmol/L.
Bleeding has continued, although back to spotting (but bright red).
I’ll redo HCG/P4 in 3 days.
**What do you think of my prospects given I’m still bleeding/spotting and low initial HCG? And your opinion on mini aspirin in this setting?
I’ve had raised NK cells in the past (done pred/clexane/IL in the past which ended in blighted Ovum so we’re trying just plaquenil this cycle)
The beta seems to be rising appropriately…so there is a possibility that the pregnancy will hold! I would do an ultrasound in about 10-14 days. That should be more definitive one way or the other..
Good luck!
Geoff Sher