Ask Our Doctors – Archive
Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.
Hi Dr Sher,
Can you please clarify this question: if only one (1) of the husband’s two (2) DQa’ genes “matches” with both the DQa genes means if women has both the DQa as same, What is the potential for the resulting embryo to become healthy pregnancy?
This represents a total match and in my opinion, if in addition there is natural killer cell activation, the chance of a viable pregnancy implanting is slim. However, if NK cell activity is normal, there should be no problem. Both a match and NK cell activity must coexist to pose an implantation problem.
Good luck!
Geoff Sher
I went into the ER last week for continued to bleed several days after my period. I started my period on a Monday with normal flow, my period last usually 5 days, on Sunday I started spotting again with pink to red blood at times. I did a home pregnancy test and it was positive so I went to ER thinking it was a miscarriage or an ectopic as I have history of both. They did an US and they did not see anything intrauterine or any mass in my tube at that time. my endometrium was 9mm, My HCG level was 57, repeated every 40 hours or so and it has been 77, 123, 261, 428. I have a repeat this Friday to see what the number is. Wont be able to have an US for at least another week or so until my numbers are high enough. They are concerned that it may be ectopic given my history and if it is not ectopic that it may end in miscarriage due to the low hcg numbers, I have not had any bleeding for three or four days now. Worried it is another ectopic as my last one ruptured.
You need to do an ultrasound in about 10 days. That should give an answer.
Geoff Sher
I’m wondering which of these two low level mosaic embryos you would recommend transferring (first)?
Del(13)(pter-q13.3)
Dup(8)(q23.3-qter)
Thank you!
Caroline,
Sorry….This needs to be discussed with a medical genetecist.
Geoff Sher
Hi Dr. Sher
I am 30 years old and discovered I had POI when I got off birth control when my husband and I were going to try to have kids. We went through the long and expensive process of finding a donor.
When we were finally ready to do the transfer, my lining wouldn’t grow, and my uterus would fill with fluid while on estrogen therapy. Our doctor tried removing the fluid every couple of days. But it didn’t seem to help the fluid or lining. Our doctor cultured the fluid, and the test revealed E. coli, but even after taking antibiotics, the fluid would return.
Our doctor performed another hysteroscopy, and there was a lot of inflammation (as there had been during the previous hysteroscopy). He removed the inflamation, and then checked the ultrasound. My lining had grown to 8.5mm and had the clear 3 lines! Our doctor was even surprised.
He didn’t want to wait for fear that staying on just estrogen would restart the inflammation/fluid, so we started my progesterone shots (I never had fluid when I was on just birth control, so he hoped the progesterone would keep the fluid from coming back).
And it did. I had no fluid on the day of transfer. My lining had thinned a little bit, but still looked good to the doctor. But 2 weeks after, when I went to get my pregnancy test, they did another ultrasound. My lining had shrunk to under 7mm and did not have the nice 3 lines anymore. And my pregnancy test came back negative.
I should add that the progesterone therapy was tough on my body, causing raised temperatures every evening (over 100 some nights) and extremely painful lumps that still haven’t gone away. So I don’t know if that had an impact on the implantation or not.
We are just at a bit of a loss right now, and feel like our doctors feel the same way. We are restarting estrogen now and hoping the fluid doesn’t come back and can just go through a normal FET cycle this time, but I don’t know if that’s realistic.
Do you have any advice for what we can do?
If you have premature ovarian failure and have not been on HRT for a prolonged period of time, the endometrium will become relatively refractory to estrogen-induced proliferation. It would need several months of cyclical E/P therrapy to restore endometrial estrogen receptors. The fluid build up can be a result of this deprivation. If I am correct, this problem is potentially reversible.
I really believe we should talk!
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INTRODUCING SHER FERTILITY SOLUTIONS (SFS)
Founded in April 2019, Sher Fertility Solutions (SFS) offers online (Skype/FaceTime) consultations to patients from > 40 different countries. All consultations are followed by a detailed written report presenting my personal recommendations for treatment of what often constitute complex Reproductive Issues.
Patients are encouraged to share the information I provide, with their treating Physicians and/or to avail themselves of my personal hands-on services, provided through batched IVF cycles that I conduct every 3 months at Los Angeles IVF (LAIVF) Clinic, Century City, Los Angeles, CA.
If you wish to schedule an online consultation with me, please contact my assistant (Patti Converse) by phone (800-780-7437/702-533-2691), email (concierge@SherIVF.com) or, enroll online on then home-page of my website (www.SherIVF.com).
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Geoff Sher
Hi, I have PCOS and never have regular periods. I had symptoms around Easter so I decided to urine test and came back positive very slightly on 04/19/2020. The following day the blood test confirmed pregnancy. On 04/28/2020 the doc gave me my hcg results 3 days apart. First HCG was 112, the second one was 865. But the doc is saying I’m barely 1 or 2 weeks pregnant. I have my first US on 05/12 but just wondering if that is even right. I see the normal ranges and I should be around 4 or 5 weeks. Should I get a second opinion? He says the baby won’t be visible through US until my levels are 6,000.
The pregnancy should be readily detectable bu US after the 6th week!
Good luck!
Geoff Sher