Ask Our Doctors – Archive
Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.
Hello Dr. Sher,
I have read many of your forums and I figured I would give you my case. In does not appear to be as in depth of some on here but anything helps.
I married my husband March of 2015 when I was 27 and he was 38. He has 3 children from his previous marriage and I have never become pregnant before. We started trying right away to become pregnant and we were unsuccessful until October of 2015 when we conceived. At 6w4d pregnant, I started spotting and I was placed on bed rest by my doctor. At 7w1d when I began to bleed much more severely I was given an ultrasound where the sac was located and the baby’s heart was beating normal. The doctor advised he could not tell me why I was bleeding and continue with bed rest. At 7w4d, I miscarried.
In January of 2016, we reached out to a fertility specialist in the city where we live. My husband’s sperm was tested and it came back excellent in all categories. We began with IUI and the doctor believed we would have no issues and become pregnant quickly.
We completed 3 IUI’s and all failed. The doctor stated he believes we had a fertilization issue and our next option was IVF.
We started IVF in July of 2016 and we successfully retrieved 19 eggs, 12 were mature and fertilized with ICSI and 7 made it to blast. We had the 7 embryos sent for PGS testing and 3 came back genetically normal.
On September 7, 2016, we transferred our genetically normal 5AA embryo (baby boy) and started the dreading two week wait. My first Beta came back at 444 and we were told I was, “good and pregnant.” My second Beta came back at 1108 and I was then scheduled for a 6 week ultrasound. 3 days after my second beta, I began bleeding extremely bad and my beta had dropped to 940 and has since dropped to 0.
When I went back to my doctor, he was rather unsure as to what happened. We transferred a genetically normal embryo, two high betas and then the sudden miscarriage. My doctor suggested we complete an ERA test to check to see if the timing of our transfer was correct. I am currently awaiting my cycle in order to begin the mock cycle for the testing.
Can a difference of a day or two of transfer cause a miscarriage? Can the uterus and lining not be “accepting” of the embryo and even though it implanted, get rid of it?
Thank,
Cheyenne K.
I doubt that ERA will provide an answer for what clear seems to be an implntation dysfunction. My greater concern is that you might have an immunologic implantation dysfunction and that it might be alloimmune rather than autoimmune in origin because this would explain most of what you have described….Please read below:
I strongly recommend that you visit http://www.DrGeoffreySherIVF.com. Then go to my Blog and access the “search bar”. Type in the titles of any/all of the articles listed below, one by one. “Click” and you will immediately be taken to those you select. Please also take the time to post any questions or comments with the full expectation that I will (as always) respond promptly.
•IVF Failure and Implantation Dysfunction:
•The Role of Immunologic Implantation Dysfunction (IID) & Infertility (IID):PART 1-Background
•Immunologic Implantation Dysfunction (IID) & Infertility (IID):PART 2- Making a Diagnosis
•Immunologic Dysfunction (IID) & Infertility (IID):PART 3-Treatment
•Thyroid autoantibodies and Immunologic Implantation Dysfunction (IID)
•Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management:(Case Report
•Intralipid and IVIG therapy: Understanding the Basis for its use in the Treatment of Immunologic Implantation Dysfunction (IID)
•Intralipid (IL) Administration in IVF: It’s Composition; How it Works; Administration; Side-effects; Reactions and Precautions
•Natural Killer Cell Activation (NKa) and Immunologic Implantation Dysfunction in IVF: The Controversy!
•Endometrial Thickness, Uterine Pathology and Immunologic Factors
•Vaginally Administered Viagra is Often a Highly Effective Treatment to Help Thicken a Thin Uterine LiningControlled Ovarian Stimulation (COS) for IVF: Selecting the ideal protocol
•IVF: Factors Affecting Egg/Embryo “competency” during Controlled Ovarian Stimulation(COS)
•The Fundamental Requirements For Achieving Optimal IVF Success
•Human Growth Hormone Administration in IVF: Does it Enhances Egg/Embryo Quality and Outcome?
•The BCP: Does Launching a Cycle of Controlled Ovarian Stimulation (COS). Coming off the BCP Compromise Response?
•Preimplantation Genetic Sampling (PGS) Using: Next Generation Gene Sequencing (NGS): Method of Choice.
•PGS in IVF: Are Some Chromosomally abnormal Embryos Capable of Resulting in Normal Babies and Being Wrongly Discarded?
•PGS and Assessment of Egg/Embryo “competency”: How Method, Timing and Methodology Could Affect Reliability
•
•Treating Out-of-State and Out-of-Country Patients at Sher-IVF in Las Vegas:
•A personalized, stepwise approach to IVF
•How Many Embryos should be transferred: A Critical Decision in IVF.
•The Role of Nutritional Supplements in Preparing for IVF
Please call or email Julie Dahan, my patient concierge. She will guide you on how to set up an in-person or Skype consultation with me. You can reach Julie at on her cell phone or via email at any time:
Julie Dahan
•Email: Julied@sherivf.com
•Phone: 702-533-2691
?800-780-7437
Geoff Sher
I also suggest that you access the 4th edition of my book ,”In Vitro Fertilization, the ART of Making Babies”. It is available as a down-load through http://www.Amazon.com or from most bookstores and public libraries.
I had an IUI done early this month…I had very sensitive breasts. Is that a pregnancy symptom? Our of curiosity I started squeezing my nipples and I see a light green discharge from the right side. Is that normal? Is it dangerous?
You could have breast pathology such as a duct pappiloma or duct ectasia. See your OB/GYN to have it checked out.
Geoff Sher
so my estrogen on 10/15 was 1,129 I was still on estrogen suppositories twice a day and 4 minivivelle patches.. I stopped the suppositories last night.. and my patches go down to 2 on 10/19 and on through a positive pregnancy test.. Will this make my estrogen drastically drop?
Hopefully not!
Good luck!
Geoff Sher
Dr Sher,
I am going through infertility issues. I have been doing treatments. This month I did my 3rd IUI on 10-5-16. I did 150 IU of Follitism and triggered ovulation with Ovidrel on 10-3-16. I started my Endometrin on 10-7-16. I still have not tested to see if I’m pregnant or not. My question is. If I am, is it ok To Notice Some light pink bleeding on the applicator (for Endometrin) when I remove it?
That is quite common. I would not be concerned unless the bleeding increases or there is significant pain.
Geoff Sher
My FET is Thursday would it be alright if I got a massage Wednesday to relax? Or would the possible toxins that can be released through a massage be an issue for embryo transfers?
Should be fine Megan!
Geoff Sher